The Scan within archives is something that increases the scan time considerably but it CAN catch some additional items that you might install in the future. I suggest turning it on, but if you keep a close eye on your system then leave this unchecked since you'll be scanning often enough that you can save the added scan time right now. If you don't plan on scanning frequently then I suggest enabling this. I don't suggest anybody use the skip non-executable files of the skip files larger than fields.

Memory & Registry
I highly suggest making sure that every single one of these options are checked!

Scan active processes - Scans ALL active/running .exe files which you can see through task manager. A must for sure

Scan Registry - This is lower priority than the processes, but a lot of times even after you've stopped the process from running there's still scraps of it sitting in your registry. This is only a basic scan

Deep-scan registry - This scans everything in your registry and will catch quite a bit more than the above scan. The downside is it can take quite a bit longer to complete.

Scan my IE Favorites for banned URLS - Alot of sites are well known for installing considerable amounts of spyware and this will give you a heads up if one of your favorite sites are known for this kind of thing.

Scan my Hosts file - This checks for things like hijackings and various redirects that some applications might put in on you without you ever noticing. I personally change my HOSTS file to read only to prevent this kind of thing from happening.

Now that we've gone over the settings lets start scanning!

On that opening page you'll see a start button. Go ahead and click on that now.